Autoinjector Case Study

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A concept of a probable autoinjector for bio-threat agents Geetha RV1, Anitha Roy1, Senthilkumar S1, Bhaskar ASB2 and Vijayaraghavan R1 1Saveetha University, Chennai ? 600077 2Defence Research and Development Establishment, Gwalior ? 474002 Short title : Autoinjector for bio-threat agents Corresponding author : R. Vijayaraghavan, Ph.D. Abstract Chemical and biological weapons can be used during conflicts and by terrorists to injure or kill humans and animals. Chemical weapons contain toxic chemicals and biological weapons contain pathogenic organisms. With proper protective equipments and training, the lethal effects of chemical and biological warfare agents can be minimised. First aid kit is available that contain detection, decontamination and medical protection for chemical warfare agents including autoinjectors, for rapid administration and faster absorption of drugs. The autoinjectors are safe and available for life saving drugs like atropine sulphate and pralidoxime chloride (nerve agent poisoning), epinephrine (anaphylaxis), diazepam (seizures) and sumatriptan (migraine). For bio-threat agents doxycycline…show more content…
When given intramuscularly the autoinjector can deliver the drugs faster with rapid absorption compared to manual injection due to the spray effect of drug delivery in autoinjector. In the autoinjectors the needle is not visible outside and hence do not cause any fear. The injection will be painless, easy to administer and well suited for mass casualty management. When healthy volunteers were administered atropine and pralidoxime chloride through autoinjectors, the drug absorption was faster by the autoinjector.5 Other than atropine sulphate and pralidoxime chloride (nerve agent antidotes), autoinjectors are available for few life saving situations viz., epinephrine for anaphylaxis, diazepam for status epilepticus, sumatriptan for migraine and midazolam for

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