Photosynthesis Lab Report

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Cochlear Inner hair cells (IHC) transmit sound stimuli by releasing the neurotransmitter glutamate onto the afferent nerve fibers (type 1 Spiral Ganglion neurons (SGN)). SGNs have α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) on their post synaptic surface, which is the major receptor involved in Ca2+ influx during sound perception. During excess sound (noise) the IHCs release excess glutamate and this leads to increased influx of Ca2+ in the SGN leading to excitotoxic trauma and the destruction of the synapse. SGN is innervated by an efferent fiber projecting from the Lateral Olivary Nuclei (LOC), which modulates the activity of SGN. Calcitonin gene-related peptide (CGRP), one such neuropeptide was shown to exacerbate

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