Crimazole Case Study

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Topical microemulsion systems for the antifungal activity containing Clotrimazole are designed to overcome the problems associated with its low solubility (0.49 mg/L) and slow dissolution in aqueous solutions. In this study, Clotrimazole was incorporated in jambhul honey microemulsion formulation without causing instability of the emulsion. The solubility of Clotrimazole in various oils, surfactants and cosurfactants was assessed to finalize the components of the w/o and o/w microemulsions. The pseudoternary diagrams were plotted to recognize the area of microemulsion region. The effect of Smix (surfactant:cosurfactant weight ratio) on the microemulsion region has been determined and optimum systems were developed. Eight Clotrimazole microemulsion formulations, each four of water/oil (isopropyl myristae/Tween 80/phophotidyl choline/water) and oil/water (oleic acid/Cremophor EL/Transcutol P/water) were prepared and evaluated. The…show more content…
albicans, Trichophyton, Malassezia and Epidermophyton. Clotrimazole’s short bioavailability after oral administration is related with its low solubility (0.49 mg/L), lipophilic character, and slow dissolution in aqueous solutions. As a result, oral drug administration leads to occurrence of neurological reactions and gastrointestinal disorders. It is a productive drug when used topically in the form of creams, gels, vaginal tablets, suppositories lozenges, and ointments. However, its low solubility is a complication in the treatment of cutaneous diseases through topical delivery. The drug should be administered to the site of infection in a topical dosage form in an adequate concentration in order to achieve effective treatment. Hence, improving its solubility and rate of release is essential to achieve rapid antimycotic activity

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