Solubility Research Paper

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Abstract Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this process may occur not only because of dissolution but also because of a chemical reaction. Solubilization of poorly water-soluble drug has been very important issue in screening study of new chemical entities and formulation research. Solubility is one of the important parameter to achieve the desired concentration of drug to the systemic circulation for its bioavailability. Oral route is the most desirable and preferred method of administering drugs for their systemic effect. Most of drugs weakly acidic and basic with poor aqueous solubility. Any drug to be absorbed must be present in the form of aqueous solution. For this various methods…show more content…
Introduction Oral route is the most preferred route of administering drugs for its systemic effect, but the major problem is poor bioavailability of drug due to its poor solubility in GIT fluid. Solubility is the property of a solid, liquid, or gaseous chemical substances called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the maximum quantity of solute in a certain quantity of solvent at specified temperature and pressure(6) Table no.1 Descriptive term for solubility (2) Descriptive term Parts of solvent required to dissolve one part of solute Very soluble Less than 1 Freely soluble More than1 but less than…show more content…
Nature of the solute and solvent only 1 gram of lead (II) chloride can be dissolved in 100 grams of water at room temperature while 200 grams of zinc chloride can be dissolved. The great difference in the solubility’s of these two substances is the result of differences in their natures. Molecular size The solubility of the substance is decreased when molecules have higher molecular weight and higher molecular size because larger molecules are more difficult to surround with solvent molecules in order to solvate the substance. Polymorphs Polymorphs can vary in melting point. Since the melting point of the solid is related to solubility, so polymorphs will have different solubility’s. Generally the range of solubility differences between different polymorphs is only 2-3 folds due to relatively small differences in free

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