Amlexanox Case Study

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Low-level laser therapy vs. FDA-approved 5% Amlexanox: A comparative study to understand the healing effects in a cohort of minor apthous ulcer patients Introduction Recurrent apthous ulcer (RAU) or recurrent apthous stomatitis (RAS) which are commonly called as canker sores are small, round, oval-shaped ulcers having yellow or gray floors and are surrounded by erythematous haloes.1 They generally occur in the oral mucosa and rarely on the gums.2 It has been observed that about 5–25% of the population are affected by the disease3,4 and it occurs more predominantly in women than in men.2 The etiology of RAU is poorly understood although some factors like genetics, stress and anxiety, immunological alterations, local trauma, microbial agents,…show more content…
A wide range of medications like antiseptics, anti-inflammatory drugs, antibiotics and corticosteroids are available for treatment. Amlexanox (C16H14N2O4) is a topical anti-inflammatory and anti-allergic drug which is mainly used as an oral paste for the treatment of RAU.14 It is the only drug which is approved by US FDA for the treatment of apthous ulcers.15 Alternatively, low-level laser therapy (LLLT) also known as ‘soft laser therapy’ or ‘bio-stimulation’ has developed as an efficient therapy for treating different kinds of oral ulcerative lesions.16 Laser treatment provides pain relief, reduces edema, and stimulates the process of tissue regeneration.17 Based on the above rationale, the purpose of this study was to compare the healing effects of LLLT and FDA-approved 5% Amlexanox in Indian patients with minor apthous…show more content…
H. Aggarwal, M.P. Singh, P. Nahar, H. Mathur, S. Gv, Efficacy of low-level laser therapy in treatment of recurrent aphthous ulcers – a sham controlled, split mouth follow up study, J. Clin. Diagn. Res. 8 (2014) 218–221. 21. M. Bladowski, H. Konarska Choroszucha, T. Choroszucha, Comparison of treatment results of recurrent aphthous stomatitis (RAS) with low- and high-power laser irradiation vs. pharmaceutical method (5-year study), J. Oral Laser Appl. 4 (2004) 191–209. 22. H. Khademi, A.M. Shirani, F. Nikegbal, Evaluation of low level laser therapy in recurrent aphthous stomatitis, J. Dent. Shiraz Univ. Med. Sci. 10 (2009) 160–162. 23. Manaf Taher Aga, Low level laser therapy as a solution in dental clinic – a review and case report, J. Oral Laser Appl. 7 (2007) 65–73. 24. T. Karu, Photobiology of low-power laser effects, Health Phys. 56 (1989) 691–704. 25. R.D. Lins, E.M. Dantas, K.C. Lucena, M.H. Catão, A.F. Granville-Garcia, L.G. Carvalho Neto, Biostimulation effects of low-power laser in the repair process, Ann. Bras. Dermatol. 85 (2010)

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