Solubility In Chemistry

1349 Words6 Pages
The term “Solubility “is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent. Solubility of a substance fundamentally depends on the solvent, temperature and pressure. Extent of solubility of a specific substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution system. [1] Solvent is generally a liquid, which can be a pure substance or can be a mixture of two liquids. The extent of solubility ranges widely, from very soluble (fully miscible) such as ethanol in water, to practically insoluble. The term insoluble is often applied to poorly or very poorly soluble compounds in the solvent system. [2] Terms of solubility shown in table 1.…show more content…
The importance of the solubility is confirmed in the Biopharmaceutical Classification System (BCS) which is a scientific framework for classifying drug substances based on their aqueous solubility and intestinal permeability. The BCS account three major factors that govern the rate and extent of drug absorption from immediate release solid oral dosage forms which are: (1) dissolution; (2) solubility; and (3) intestinal permeability. According to the BCS, drug substances are classified as

More about Solubility In Chemistry

Open Document