L-Proline-promoted one pot synthesis of quinoline sulfonamide derivatives in neat water under microwaves and their antioxidant and anticancer activities as Carbonic anhydrase inhibitors.
Docking studies, synthesis, characterization of quinoline sulfonamide derivatives in neat water under microwaves and evaluation for their antioxidant and anticancer activities as Carbonic anhydrase inhibitors.
A green and efficient one-pot process (MCRs) to achieve quinoline sulfonamide derivatives, using a three component reaction involving sulfanilamide, aldehydes and malononitrile was developed. This protocol was accomplished efficiently using L-proline as catalyst in an aqueous medium to give the corresponding products in high yield. The activity of L-proline in these reactions was tested over a set of aldehydes and amines, demonstrating that it is reactive towards a variety of functionalities.…show more content… Results and discussion:
This is an environmentally benign microwave assisted and efficient method for rapid synthesis of the quinoline sulfonamide derivatives. The main eco-friendly attributes of this process are solvent and green catalyst conditions. The reaction protocol includes advantages of use of green catalyst, short reaction time and easy work-up or purification step, high purity as well as yield of the product.
A greener and more facile procedure for the synthesis of quinoline sulfonamide derivatives was developed by using different aldehydes, sulfanilamide, malononitrile and L-proline as catalyst under microwave irradiation in neat condition. (Scheme 1). In an approach, 1 equiv of sulfanilamide, 1 equiv substituted aldehydes, and 1 equiv of malononitrile were dissolved in water and reaction mixture was irradiated under the microwave at a power level of 200 W for 35–40s in presence of L-proline as a catalyst. The progress of the reaction was duly checked by TLC. The products were isolated by simple and usual work up with 80–92 % of yield