Mevacor Case Study

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“ DRUGS ” MEVACOR : Mevacor (Lovastatin ) is drug that is statin, used for decreasing the levels of cholesterol in people to decrease the risk of cardiovascular disease and who are suffering from diseases like hypercholesterolemia. It is a naturally found compound and low concentrations of it are available through food like oyster mushrooms, red yeast rice and Pu-erh. HISTORY : In 1970’s ,two naturally occuring products Mevacor and Compactin are clinically developed for lowering the cholesterol as potential drugs. They are used due to their powerful inhibitory effect over HMG-CoA reductase. Around 1982 time, Some clinical investigations had been carried out over Mevacor to test the Toxic effects by experimenting over high-risk…show more content…
A major rate-limiting step in the pathway is at the level of the microsomal enzyme that catalyzes the conversion of HMG CoA to mevalonic acid, and that has been considered to be a prime target for pharmacologic intervention for several years. The conversion of HMG-CoA to Mevalonic acid catalysed by microsomal enzyme is the major rate determining step in the pathway and it has been considered to be a main target for several years by pharmacologic intervention. In this biosynthetic pathway,HMG CoA reductase occurs early and is among the committed steps for formulation of cholesterol initially. Accumulation of HMG CoA,which is a water-soluble intermediate is achieved by inhibition of this enzyme and then it is capable of being readily metabolized to simpler molecules and Accumulation of lipophylic intermediates with a formal sterol ring is achieved through inhibition of reductase. And some years later clinitians came up with the discovery of the Mevacor, a fungal metabolite which is novel and its structure was determined to be different from that of Mevastatin due to the presence of hexahydronaphthalene ring containing 6 alpha methyl groups. Bio-synthesis of Mevcor by Diel’s-Alder catalysed cyclisation…show more content…
Molecular Formula : C35H46O14 Molecular Weight : 690.73134 It is also called as “ Squalestatin 1 ” . ZARGOZIC ACID A Zaragozic acids are inhibitors of sterol synthesis due to their functionality as potential inhibitors of fugal and squalene synthase. In sterol synthesis, Squalene synthase acts as a enzyme which forms squalene from the condensation of farnesyl pyrophosphate by reduction through catalysis. In primates, Plasma cholesterol levels are low which are produced by Zaragozic acids is due to the inhibitor ability of squalene synthase. Increase in Low density lipoprotein receptor mRna levels which are hepatic in rats is due to the usage of Zaragozic acid A over them. "Amauroascus niger" is the name of the fungus from which Zaragozic acid D & D2 has been isolated.

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