Drug Delivery System Case Study

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1.1 INTRODUCTION TO NOVEL DRUG DELIVERY SYSTEM The pharmaceutical industry is changing day to day based on the changing patient needs and overall developments. It has diverted their research focuses on conventional dosage forms to novel drug delivery systems which have got considerably enhanced market needs. It would be always an encouraging for units developing novel delivery systems to sustain their market presence & share. The cost of development a new drug entity is also higher. Therefore efforts have been made by pharmaceutical industries and researchers to focus on the development of novel dosage forms for present drug molecule. Drug delivery system is a valuable tool for augmenting market, continuing product life cycles and generating…show more content…
This includes Cellulose Acetate Phthalate, Shellac, Zein, Polyvinyl acetate phthalate, Hydroxy Propyl Methyl Cellulose Phthalate and Acrylate polymers etc. These polymers are become insoluble in gastric juice because of it becomes protonated at low pH of stomach and are ionized as well as become soluble in the alkaline pH of small intestine. The pH-dependent solubility is largely assessed by the degree of substitution of acidic functional groups and the pKa value.[8] In gastrointestinal tract, the range of pH value from the stomach to colon is from 2 to 7. In view of the fact that pH varies in the different parts of GI tract, it would be possible to manipulate drug release within the required pH range by blending two polymers with each other at different ratios. As their nature are pH dependent, they are used for different purposes such as: • To protect the gastric mucosa from irritation by drug, • To prevent degradation of the drug by enzymes or acidic fluids in the stomach, • To deliver the drug quickly to a specific region like upper part of the small • To deliver pH sensitive drug or pharmaceuticals such as proteins and therapeutic…show more content…
of reasons as described under: On oral administration of multi-particulate dosage form, the subunits of multiple-unit preparations distribute readily over a big surface area in the GIT and the particles which are less than 2 mm size behave like liquid leaving the stomach rapidly. The well-distributed particles could improve the bioavailability and also could result in a decrease in local drug concentration, risk of toxicity, and side-effects. Multiple-unit dosage form offers ease of adjustment of the strength of a dosage unit. It is also possible to administer two incompatible drugs in a single dosage unit by separating them in different multiparticulates. Multiple-unit dosage form offers design of desired overall drug release profile by combining the multiparticulates with different drug-release

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