Zidovudine Case Study

1689 Words7 Pages
Objective: In the present study, an attempt was made to improve the bioavailability of Zidovudine by formulating into Orodispersible tablets, as it has poor bioavailability and extensive pre systemic metabolism. Methods: In the present study, the mucilage extracted from Fenugreek seeds (Trigonella foenum-graecum) was used as superdisintegrant. The oral dispersible tablets were prepared by using wet granulation technique. A three factor two level (23) central composite design was employed for the optimization of formulation. The input variables chosen are amount of fenugreek mucilage, amount of mannitol, and concentration of PVP and the response parameters chosen for the optimization were Dissolution efficiency at 10 min and In-vitro dispersion time. Data analysis was carried out by multiple linear regression analysis. Differential Scanning Calorimetry (DSC) and Attenuated total reflection (ATR) reports shown that there is no interaction between drug and excipients. Results: Four optimized formulations F1 to F4 are selected from the numerical optimization technique. The prepared formulations were evaluated for different pre-compression and post-compression parameters. The In-vitro dissolution studies were carried out as per USP. The…show more content…
Accurately weighed quantities of Zidovudine, mannitol, fenugreek mucilage and other excipients were passed through sieve number 10 (as per Indian Pharmacopoeia) and mixed in a glass mortar. The above blend was granulated with a non-aqueous granulating agent, alcoholic solution of PVP (5 or 10%w/v), and passed through a sieve of aperture size, 710 µm. The granules were air-dried, mixed with 2%w/w Talc and 2% w/w Magnesium stearate and the granules were passed through sieve number 22, (as per Indian Pharmacopoeia). Granules were compressed by using embossed C25 concave punches in multi station tablet compression machine

More about Zidovudine Case Study

Open Document