Co-Processing Case Study

1050 Words5 Pages
INTRODUCTION: Co-processing is based on the novel concept of two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvement as well as masking the undesirable properties of individual.1 Development of co-processed excipients starts with the selection of the excipients to be combined, their targeted proportion, selection of preparation method to get optimized product with desired physico-chemical parameters, and it ends with minimizing batch-to-batch variation.2 Co-processing is interesting because the products are physically modified in a special way without altering the chemical structure. Tablet disintegration is a prerequisite to fast release of active ingredients…show more content…
For example, the swelling of some disintegrant particles is dependent on the pH of the media.7 Significant reductions in the rate and extent of water uptake and swelling were observed for both sodium starch glycolate (Primojel) and croscarmellose sodium (Ac-Di-Sol) in an acidic medium (0.1 N HCl) but not for crospovidone (Polyplasdone XL10), a nonionic polymer.8 A formulation containing acetaminophen and crospovidone with or without sucrose, did not show big dissolution difference between acidic and neutral media, which correlates well with the disintegration study. In contrast, a formulation containing acetaminophen, sucrose and croscarmellose sodium caused longer disintegration and slower dissolution in the acidic medium than those in the neutral…show more content…
It represents the second most abundant polysaccharide found in nature, next to cellulose. The main commercial sources of chitin are the shell wastes of shrimp, crab, lobster, krill, and squid. Chitin is mainly used for production of chitosan by a deacetylation reaction usually obtained in alkaline medium. Chitosan exhibits several favorable properties such as biodegradability and biocompatibility Chitosans have been developed for a variety of pharmaceutical applications.15 In comparison with other commonly used tablet binders, the binding efficiency of chitosan was between hydroxypropyl methylcellulose and methylcellulose.16 Disintegration time for matrix tablets containing 7% chitosan was significantly faster than those containing corn starch and microcrystalline cellulose, and slower than those containing sodium starch glycolate and croscarmellose sodium.17 Spray dried chitosan has also been evaluated as a direct compression excipient for tablets which showed excellent flow and were suitable for

More about Co-Processing Case Study

Open Document