Coronary Artery Disease Hypertension

1655 Words7 Pages
The most common problem in type 1 and type 2 diabetic patients is hypertension. (Epstein et al., 1992) Cardiovascular disease is most common type of diabetes complication of type II diabetes and represent 50-80% of the deaths among patients with diabetes. Therefore, prevention of this complication is an important goal for treatment of diabetes (Li, Y et al., 2014).‏ Hypertension is a risk factor for coronary artery disease, heart failure (HF), stroke, and chronic kidney disease. (Lithovius et al., 2013) ‏When hypertension is coexists with diabetes is not only an indication of the increase risk of mortality, but it also contributes to the development of diabetes. (Goyal et al., 1996) Co-existence of hypertension and…show more content…
Metabolism process occur by two basic types of reaction. The first, so-called Phase I reactions (consist of oxidation, reduction or hydrolysis reaction), in phase I metabolism the drugs convert into more polar compounds, while Phase II reactions involve conjuncts drugs with other substance (e.g. glucuronic acid, or amino acid) to convert it usually into inactive compounds. So a metabolic process that is generally affected is oxidation in Phase I reaction, this term comprise a numerous of metabolic biotransformations, Presence of NADPH and the haem-containing protein cytochrome P450 are required to all of these biotransformations. When cytochrome P450 enzyme induction occurs the amount of endoplasmic reticulum within the liver cells rises and the amount of cytochrome P450 also increases. Induction of cytochrome P450 enzyme is a most common mechanism of interaction, not only limited to the drug, but goes beyond that to caused by the chlorinated hydrocarbon insecticides such as dicophane and lindane, and after smoking tobacco. Some drugs can stimulate the actions of the microsomal enzymes, so there are others, which have the contradictory impact, and act as inhibitors of the microsomal enzymes. So that the metabolism of other drugs administrated concomitantly also decreased and they begin to accumulate inside the body causing toxicity, enzyme induction may take several days or even weeks to cause a complete induction a complete induction, on the other hand, enzyme inhibition can occur within two to three days leading to the rapid development of

More about Coronary Artery Disease Hypertension

Open Document