Inhibition Of COX-1

1051 Words5 Pages
1. Describe the mechanism of action of the NSAIDS. Traditionally, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has been explained on the basis of their inhibition of the enzymes that synthesize prostaglandins. However, it is clear that NSAIDs exert their analgesic effect not only through peripheral inhibition of prostaglandin synthesis but also through a variety of other peripheral and central mechanisms. It is now known that there are 2 structurally distinct forms of the cyclo-oxygenase enzyme (COX-1 and COX-2). COX-1 is a constitutive member of normal cells and COX-2 is induced in inflammatory cells. Inhibition of COX-2 activity represent the most likely mechanism of action for NSAID-mediated analgesia, while the…show more content…
Other side effects include but are not limited to a hypersensitivity pneumonitis, septic meningitis, , thrombocytopenia, erythema nodosum, interstitial nephritis, erythema multiform, fixed drug eruptions, toxic epidermal necrolysis, Stevens-Johnson syndrome, and maculopapular eruptions. 5. What are some of the major side effects of the NSAIDS? The most serious side effects of NSAIDs are bleeding, kidney failure, ulcers, and rarely, liver failure. 6. Who should not be taking NSAIDS? Explain the rationale. One should not use an NSAID to treat pain after a coronary artery bypass graft surgery. You may have an allergic reaction if you suffer from asthma or are allergic to an ingredient in the NSAID People taking blood thinners such as warfarin (Coumadin) or Eliquis should not be taking NSAIDs this is because it poses a risk of major bleeding. Children are at a risk developing Reye's syndrome, if aspirin is taken for chicken pox, influenza and other viral diseases. 7. Cross-sensitization can occur with the NSAIDS. What does this term…show more content…
What is the mechanism of action of sumatriptan (Imitrex)? Besides the triptans, what other classes of drugs can be used in the treatment of migraine headaches? Sumatriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine and cluster headaches through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. Besides triptans other drugs for treating migrane headaches include, Ordinary painkillers (paracetamol), Anti-inflammatory painkillers (ibuprofen), and Anti-sickness medicines ( MigraMax, Paramax). 11. Describe the mechanism of action of the opioid analgesics. Opioid analgesics bind to a number of different receptors throughout the body—mu, delta, and kappa.8 The binding to these different receptors results in both the therapeutic and adverse effects of opioid analgesics. Genetic variations in the structure of these receptors can partially explain interindividual responses, including some adverse reactions to these

More about Inhibition Of COX-1

Open Document