Dopamine Research Paper

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Rohini Mukherjee NEU 301 Dr. Symonds Dr. Maizei-Robinson Dopamine and Parkinson’s Dopamine produced in dopaminergic neurons ventral tegmental area (VTA) of the midbrain, the substantia niagra pars compacta, and the arcuate nucleus of the hypothalamus. It is activated from protein synthesis in the dendrites and binds to G protein coupled receptors. There are several issues that come with having low levels of dopamine, including but not limited to: learning and memory problems, depression, anxiety, and cognitive impairment. Low levels of dopamine is also something that is seen with Parkinson’s patient so it may also have an effect…show more content…
They selected PLGA to deliver dopamine in the brain the put dopamine in one of the PLGA’s and florescent IV in the other two PLGAs for a control. They went through a series of checks to test to make sure to the PLGA’s were ready to be put into the rats starting with Transmission electron microscopy (TEM), to check the size of them to make sure they weren’t too large. Then they studied the release of the dopamine from the PLGA’s to make sure the release was slow enough is phosphate buffer saline. Physical stability mitochondrial activity were also checked before getting a in vivo study in plasma to make sure everything was working properly before finally being put into the striatal region of the rat brain and running a series of tests to see how effective the PLGAs…show more content…
No side effects sounds a lot better and optimistic but it does raise expectations when you talk about a study that found a way to reverse the effects of Parkinson’s with no side effects. If you don’t have a good understanding of how this process works it makes it sound like a miracle drug could be coming out soon when really it’s still too early to tell if it’s as good it sounds. The same also applies to the Parkinson effects. The research article is more specific on what their study showed, neurochemical and neurobehavioral symptoms of Parkinson’s. The media article was broader, it said that it reversed the movement problems. The biggest difference however is the word choice the media article talked more in definite terms. The media article starts out with an issue that Scientists are dealing with concerning Parkinson’s, crossing the blood brain barrier, and the research article dealing with the issue it seems very open and shut. The research article talks more in maybes, this might prove to be a way to reverse the effects. This is because there are still many tests go through before they know for sure. However the media’s job is to sensationalize and saying something could reverse the neurochemical deficits of Parkinson’s is not as exciting as potential treatment of

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