Atorvastatin Case Study

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. DRUG PROFILE 4.1 ATORVASTATIN Atorvastatin marketed under the trade name of Lipitor. It is a member of class known as statins. Which are known as primarily lipid-lowering agent and prevention of events that are associated with cardiovascular disease. Like all the statins Lipitor work by inhibiting HMG-CoA reductase, an enzyme present in the liver tissue and it plays a major role in our body for the production of cholesterol. Atorvastatin and the other statins work potentially decreasing the production of cholesterol in our body by blocking the cholesterol-producing enzyme in the liver. Excessive production of cholesterol in arteries may block the blood flow to the heart, brain and the other parts of the body which…show more content…
As decreased hepatic cholesterol level stimulates up regulation of hepatic LDL-C receptor which mainly increases the hepatic uptake of LDL-C and reduces serum LDL-C concentration. [Ahjel S.W., Lupuleasa D. (2009),] 4.1 (b) MOA of statins cholesterol synthesis pathway. [Wade A, Weller PJ. 1994] Acetyl CoA HMG-CoA synthase HMG-CoA HMG-CoA reductase & statins Mevalonic acid Mevalonate pyrophosphate Isopentenly pyrophosphate Gerany pyrophosphate Squalene Cholesterol 4.1 (c) Pharmacodynamic Atorvastatin and some of its metabolites are pharmacologically active in humans. Liver is the major site of action and the principal site of cholesterol synthesis and LDL clearance. It is the dosage of Atorvastatin rather than the systemic drug concentration which correlates with extent of LDL-C…show more content…
Side effects which are less serious < Digestive system side effects  Diarrhea  Constipation  Dyspepsia  Flatulence < Respiratory system side

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