Short Nerve Injury Analysis

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Each year, nearly hundred thousand patients undergo peripheral nerve surgeries in Europe and U.S[1]. Although there are ample microsurgery techniques available for short nerve lesions, our ability to bridge long peripheral nerve gaps remains unsatisfactory[2]. Current approaches focus on enhancing axon growth by direct action on nerves, or glial cells, but here we investigate a novel approach to influencing regenerative outcomes by biasing the inflammatory sequence early after the injury[3][4]. After an inflammatory insult, macrophages that accumulate at the site of injury appear to be largely derived from circulating monocytes[5][6]. In rat, monocytes include two major subsets (CX3CR1 low and high) which appear to be specialized for different

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