Pharmaceutical Suspension Lab Report

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INTRODUCTION In this lab practical, students need to prepared suspension by adding suspending agent and different type of surfactant A pharmaceutical suspension is a coarse dispersion in which insoluble solid particles are dispersed in a liquid medium. Particles of suspension are visible to the naked eye when they are left floating around freely in a solvent. The internal phase (solid) is dispersed throughout the external phase (fluid) through mechanical agitation, with the use of certain excipients or suspending agents. Unlike colloids, suspensions will eventually settle. A simple example of a suspension would be sand in water. A suspension must be prepared to make them remain sufficiently homogenous between the shaking and removal phase.…show more content…
So therefore they do not dissolve in mostly liquid vehicle. Water is the most common vehicle used for pharmaceutical suspension formulation due to their lack of toxicity. But as we know most drug are hydrophobic that once dispersed in aqueous solution they will acquire a charge. As hydrophobic materials, they will generally repel water, so the materials will not soluble and dissolve in the water. The distribution of the charge will result in two distinct region that will form an Electrical Double Layer (EDL). Electrical double layer is the structure of charge accumulation and charge separation that always occurs at the interface when a solid is immersed into an aqueous solution. The excess charge on the solid surface is compensated by an accumulation of excess ions of the opposite charge in the…show more content…
The stability is dependent upon the total potential energy function between them. This theory calculates the energies of attraction and repulsion between similar particles and predicts the overall energy of interaction. From this, we could estimate whether the particles coalesce and settle or remain evenly dispersed throughout the medium. To calculate the total energy interaction between two particles (VT), the value between energy of Van Der Waals attraction (VA) and the energy of electrical repulsion (VR) are summed as follow (VT = VA + VR). There are three important part in the DVLO digram which are the primary minimum, primary maximum and secondary minimum. The behavior of the suspension depend on which zones the particles are
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