Oral Dispersible Tablets Case Study

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Oral dispersible tablets are an innovative technology, which disperse rapidly without the need for water, providing optimal convenience to the patient. Ondansetron is a selective 5-hydroxytryptamine type3 receptor antagonist used to treat chemotherapy and radiotherapy induced nausea and emesis. The aim of this study was to formulate effective taste-masked orally dispersible tablets of Ondansetron hydrochloride to get rapid onset of action, to increase bioavailability and to increase patient compliance. The bitter taste of the drug was masked by incorporating in the resin, Kyron T-134 (A weak acid cationic resin) by adding drug to the slurry of Kyron T- 134 in distilled water. The formulations were prepared by direct compression method using…show more content…
In all the formulation thickness varies between 3.16 to 3.26mm and hardness of the optimized batch was found to be 3.2 kg/cm2. No variation in the hardness was found in the optimized batch which clearly indicates that the blending was uniform. The prepared tablet in the optimized formulation possessed good mechanical strength with sufficient hardness. Friability was less than 1% in the entire batches. The entire tablet from each formulation passed weight variation test, as the % weight variation was within the pharmacopeial limit of ± 7.5 % of the weight. The weight variation in all the formulations was found to be 80 - 83.5 mg which was in the pharmacopeial limits. The percentage drug content of all the formulation was found to be 99-102.5% of ondansetron hydrochloride. The in-vitro disintegration time for all the formulations varied from 15-52.5 sec. The rapid disintegration was seen in the formulation containing polyplasdone XL10 (S13- 15sec). The drug release was found to be more than 90 % within 10 min. Stability studies were also performed for the optimized formulation and the results were
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