Linearity Lab Report

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Figure 10. Linearity graph on standard in Acetat, HCl, and phosphate medium Accuracy Accuracy test are performed to obtain a percent recovery analit in matrix sample. For dissolution test, the accuracy test was conducted by spike placebo method in 3 different concentration that is 40%, 75%, 110% [11]. Typical accuracy of the recovery of the drug substance in the mixture is expected about 95–102% [14]. Table 3.2. The results of the accuracy test in the matrix in the HCl medium Concentration (%) Replication Theoretical content (ppm) Levels obtained (ppm) % recovery Average ± RSD (%) 40 1 2 3 20 20,12 19,94 19,71 100,6 99,7 98,55 99,62 75 1 2 3 37,5 38,72 38,59 37,25 103,26 102,9 99,35 101,84 110 1 2 3 55 55,87 56,22 55,98 101,58…show more content…
One of three concentrations on accuracy was conducted by 6 replicates. Repeatability test were conducted at the standard concentration of 40% in the matrix solution in HCl medium, the standard concentration of 75% in the matrix solution in the acetate medium, and the standard concentration of 110% in the matrix solution in phosphate medium with the spike placebo method. The related standard deviation (RSD) of third the test was 1.8%, 1.23%, 1.68%, which is clearly indicated that RSD is ≤ 2%. LOD and LOQ Detection limits and quantitation limits were determined by injecting standard solutions in HCl, acetate, phosphate mediums with concentrations of 5, 10, 20, 30.40,50 and 60 ppm, respectively at selected HPLC conditions. The results were processed by making the regression equation, it was y = bx + a. The slope value of the regression equation and sy (standard residual deviation) is used to determine the limits of detection and quantitation limits. LOD = (3 x SD)/slope LOQ = (10 x…show more content…
The maximum surfactant is used 1% [11], in the previous study, sodium lauryl sulphate (SLS) was used as a surfactant with concentrations of 0.1%, 0.5%, 1% [13]. The present study, surfactants with a concentration of 0.5% provided the highest drug release profile with greater stability, and ensured excellent sink conditions in accordance with the ethyl acetate-96 fraction tablet content of 7,4 % w/v
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