vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. Besides triptans other drugs for treating migrane headaches include, Ordinary painkillers (paracetamol), Anti-inflammatory painkillers (ibuprofen), and Anti-sickness medicines ( MigraMax, Paramax). 11. Describe the mechanism of action of the opioid analgesics. Opioid analgesics bind to a number of different receptors throughout the body—mu, delta