Of Mice and Men John Steinbeck’s Of Mice and Men uses a variety of literary elements to help the reader acquire a better understanding of the text and how it shows us The setting in which Of Mice and Men takes place is a significant element in the story, and takes place during a critical time in American history: the Great Depression. People have been left poor and desperate for work all over the country (Shmoop Editorial Team). Such difficult conditions are what help set up the situations that