Plasmodium Falciparum Case Study

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I56/82896/2015 GENETIC TRANSFORMATON OF PfMDR1 GENE IN Plasmodium falciparum. Malaria has became a pandemic disease in many regions of the world for instance Africa, South east Asia, South America and Western Pacific. The Plasmodium falciparum is the species of interest in Malaria, where Plasmodium falciparum is a parasite harbored by mosquitoes (for instance Anopheles gambiae and Anopheles Arabiensis)as the vector. According to WHO 2015 report, there are 214 million incidence of malaria worldwide, it has claimed approximately 438,000 lives annually most of which are children under five years of age. P.falciparum has become a big challenge not only because it causes malaria but also due to the fact that it is developing resistance to the most…show more content…
From this technique, it was concluded that there is a DV function related to PfMDR1in mature gametocytes yet separate from haemoglobin metabolism. REFERENCES. (Dynamics of transmission of plasmodium falciparum by Anopheles arabiensis and the molecular forms M and S of Anopheles gambiae in Dielmo, Senegal.) (Mamadou Ousmane Ndiath, Cécile Brengues, Lassana Konate,Cheikh Sokhna, Christian Boudin, Jean François Trape and Didier Fontenille.) (Gobally prevalent PfMDR mutations modulate plasmodium falciparum susceptibility to artemisinin-based combination therapies.(M. Isabel Veiga1,2,*, Satish K. Dhingra1,*, Philipp P. Henrich1, Judith Straimer1, Nina Gna ̈dig1, Anne-Catrin Uhlemann3, Rowena E. Martin4, Adele M. Lehane1,4 & David A. Fidock1,3 ) (CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs ) (Caroline L. Ng,1* Giulia Siciliano,2 Marcus C. S. Lee,1† Mariana J. de Almeida,1 Victoria C. Corey,3 Selina E. Bopp,3‡ Lucia Bertuccini,4 Sergio Wittlin,5 Rachel G. Kasdin,1 Ameჼlie Le Bihan,6 Martine Clozel,6 Elizabeth A. Winzeler,3 Pietro Alano2 and

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