Stevens-Johnson Syndrome Case Study

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Introduction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis is a potentially deadly skin disease that usually results from a drug reaction. This form of the disease can be deadly as well as very painful and distressing. Stevens-Johnson syndrome can affect any age group. The incidence of SJS is estimated at 1 to 6 cases per million. Although the majority of cases are idiopathic (without a known cause), the main class of known causes is medication, followed by infections and, rarely, cancers. Drugs are an important cause of SJS in about 95%. Various categories of medication have been identified as triggers for SJS, like non-steroidal anti-inflammatory drugs (paracetamol, numesulide), anti-epileptic drugs (phenytoin, carbamazepine, valproic acid) and antibiotics (penicillin, tetracycline, and cephalosporin). Infections or a combination of infections and drugs have also been reported as the etiology of the syndrome. In case reports and studies, more than 100 drugs have…show more content…
The total percentage of the skin involved is 17%. Nikolsky’s sign is positive.The clinical dermatological picture and medical history allowed us to make an initial diagnosis of Stevens Johnson syndrome (SJS), likely triggered by the administration of ciprofloxacin. a hypothesis that was confirmed by the prompt resolution of the clinical status following the Injection dexamethasone 0.5 mg one time a day, and topical therapy with a fusidic acid 2% + hydrocortisone acetate 1% based cream, three times per day, vitamin E cream to lips two times a day IV fluids of normal saline (NS) at a rate of 100ml/hr were given. The patient was reviewed on daily basis and at the end of 1 week there was significant heeling of the hyper pigmentation and the exfoliated

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