Huntington Disease Research Paper
274 Words2 Pages
Huntington disease is a progressive and a neurodegenerative disorder characterized by involuntary movements, severe emotional disturbance and cognitive decline. This is an autosomal dominant neurological illness caused by the expansion of a CAG triplet in the exon 1 of HD gene on the chromosome 4p16.3, which causes an expanded polyglutamine repeat in the Huntingtin protein. HD does not have an appropriate cure or treatment to keep the development of the disease low. Huntingtin protein causes neuronal dysfunction in striatum, a part of basal ganglia and cerebral cortex. HD usually affects the middle aged people over children and old people. Sometimes children from aged 2-3 or old people aged above 80 also get affected due to this HD disease.