Perhaps the easiest type of writing is the conversations style we use in our everyday correspondences with friends. Marked by a distinctly colloquial tone and subjective viewpoints, this level of usage features short and choppy sentences, and it may even include fragments or run-on sentences. Moreover, the diction is usually quite simple and may include clipped words (such as flu instead of influenza), profanities, and slang. This level of usage is inappropriate for college writing, but is often utilized in casual emails, such as the one below:
Literally, this year has been hella salty. Like, you don't even know man. the english teacher is a bully. Like, he's makin me expresss myself, its bullshit! I can't…literally, i cant. Anyways, I'll be hella salty if you dont respond. (Khan)
Note how the overall tone of email is quite chatty; the author even directly refers to his audience by using the pronoun you. In addition, the sentences in this email are quite short—just seven words on average—and one of them is even a run-on that lacks proper punctuation. Furthermore, the word choice in this…show more content… hdCK3mut is smaller than HSV-TK, which is beneficial in constructing therapeutic vectors that have size limitations. hdCK3mut is more sensitive than alternative PET reporters, allowing for increased signal at sites expressing hdCK3mut (26). The engineered substrate affinity of hdCK3mut is toward thymidine analogs (27, 28), while HSV-TK is engineered toward acycloguanosine substrates (29). In some chemotherapy and bone marrow transplant regimens, a continuous administration of acycloguanosine compounds is given as prophylactic antivirals, limiting the use of HSV-TK in these settings (18, 25). The use of hdCK3mut as a PET reporter would allow for the continuous treatment with such antivirals.