Fanconi Anemia Research Paper

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Fanconi Anemia Project Fanconi anemia is a rare hereditary disease illustrated by bone marrow failure, developmental anomalies, a high frequency of myelodysplasia with severe non-lymphocytic leukemia, squamous cell carcinoma of the head and neck, and cellular hypersensitivity to cross linking agents. The task of the proteins is fairly not known, but most of these form complexes with each other while in one canonical “pathway” 7-8 of the Fanconi anemia (FA) proteins bind together in a nuclear complex. The formation of this so nuclear “core complex” permits FANCL, a ubiquitin ligase and component of the core complex, to catalyze the monoubiquitination of 2-3 proteins not found in the core complex, FANCI & FANCD2. This funding occasion will use

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