Intermolecular Forces Thermodynamic properties of any pure substance are determined by intermolecular forces, which operate between the molecules of the substance. Similarly, thermodynamic properties of a mixture depend on intermolecular forces that operate between the molecules of the mixture. In order to interpret and correlate thermodynamic properties of solutions, it is therefore necessary to have some understanding of the nature of intermolecular forces. There are many different types of intermolecular