DRUG PROFILE
AMOXICILLIN [37,52]
Properties
Formula: C16H19N3O5S
Molecular weight: 365.4 g/mol
Description
Amoxicillin is a Semisynthetic antibiotic, belonging Beta-lactum family, which is effective for bacterial treatment, especially for helicobacter pylori infection.
Solubility in aqueous or organic solvents
Amoxycillin Slightly soluble in water, in ethanol (95 per cent) and in methanol; practically insoluble in chloroform, in ether and in fixed oils. It is soluble in dilute solutions of acids and of alkali hydroxides.
Pharmacokinetic Data
Pharmacokinetic bioavailability 95 % oral, Metabolism less than 30% biotransformed in liver, Half-life6 1.3 minutes
PANTOPRAZOLE [38]
Properties
Molecular formula:…show more content… The bulk density of a powder is the ratio of the mass of an untapped powder sample and its volume including the contribution of the inter particulate void volume. Hence, the bulk density depends on both the density of powder particles and the spatial arrangement of particles in the powder bed. The bulk density is expressed in grams per milliliter (g/ml) although the international unit is kilogram per cubic meter (1 g/ml = 1000 kg/m3) because the measurements are made using cylinders. It may also be expressed in grams per cubic centimeter (g/cm3). It is defined mathematically…show more content… Mass of granules (gm) Bulk Volume of Packing (ml) Tapped Volume of Packing (ml) LBD
(gm/cm3)
TBD
(gm/cm3) (%) Carr’s Compressibility Index Haussner’s ratio Angle of Repose (θ)
PAN-1 3 6.3 4.4 0.476 0.681 30.22 1.430 38.80
PAN-2 3 8.1 6.9 0.370 0.434 14.92 1.17 29.57
PAN-3 3 8 6.5 0.375 0.461 18.77 1.22 27.82
PAN-4 3 6.9 5.8 0.434 0.517 16.05 1.18 36.02
PAN-5 3 8.2 7.1 0.365 0.422 13.63 1.15 29.35
PAN-6 3 7.8 6.3 0.384 0.476 19.36 1.23