All manufacture of paracetamol follows PNCB process route. Manufacturers of paracetamol in India use PNCB route and iron / hydrogen reduction to obtain Para amino phenol (PAP), an intermediate for paracetamol. Chlorobenzene with hydrolysis is carried out by the reaction of 9% caustic soda solution with pnitrochlorobenzene. The reaction mass is filtered and with appropriate process control and proper design of the reactor, the yields are optimized, leading into lower requirement of inputs and production
Paracetamol, as known as acetaminophen , is widely available nowadays and has found since 1950s. It is widely prescribed and affordable over-the-counter, making it a common drug used in overdose. It is a superior analgesic and an antipyretic. It is normally found as a 500 mg tablet, but it is often combined with other active ingredients in various preparations. It is a commonly used over-the-counter analgesic-antipyretic drug (pain killer) and antipyretic (fever reducer). Paracetamol decreases