Thiadiazole Case Study

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1. Introduction 1.1. Thiadiazole compound Thiadiazole is one of the most important classes of heterocyclic ring that have a promising structure for drug discovery , thiadiazole possess a wide range of pharmacological activities. This nucleus has been investigated before and known to have interesting broad range of biological activity as antimicrobial, anti-inflammatory, anticonvulsant , anti-tumor ( d,e,f) and antihyperlipidemic activity (c*). Thiadiazole is a five-membered heterocyclic ring containing one sulfur and two nitrogen atoms, which is a bioisostere of pyrimidine and oxadiazole . Thiadiazole is a mesoionic system with good liposolubility that able to cross the cellular membrane and exert its biological activity. (h) Thiadiazole…show more content…
Hyperlipidemia will involve elevation level of one or more lipid in blood stream which include , low density lipoprotein (LDL) cholesterol ,triglyceride(TG) and total cholesterol (TC) in addition to a decrease in high density lipoprotein (HDL) cholesterol (g*) .This condition divided into two subtypes which are: primary hyperlipidemia and secondary hyperlipidemia. Primary hyperlipidemia, which also known as familial hyperlipidemias caused due to a genetic factors as mutation within receptor protein, while secondary hyperlipidemia happens as a consequence of other disease as diabetes mellitus ,hypothyroidism, renal failure ,obesity and consumption of high fat diet…show more content…
1.3.1 Hyperlipidemia and its impact on health Because of modern life style , physical inactivity and consumption of high-fat diet; the incidence of hyperlipidemia have increased worldwide and become a serious public health problem and a major high risk factor for development of coronary heart disease which is responsible for the increase in morbidity and mortality rates .(i*) World health organization (WHO) have estimated that hyperlipidemia is responsible for third of coronary heart disease worldwide, causing 2.6 million deaths approximately of 4.5 % of total and 29.7 million disability adjusted life years (DALY) or a total 2% of DALY (f*). Coronary heart disease is a condition, characterized by narrowing the small blood vessels (arteries) that supply blood and oxygen to the heart, result in slowing down or stop the blood flow to the heart, this narrowing of the arteries is due to the deposition of plaque inside the artery wall, and mainly this plaque consists of lipid (fat).(l*) 1.3.2 Antihyperlipidemic

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