Pglo Lab

425 Words2 Pages
Introduction: The process of transferring genetic information from one organism to another is called transformation. This can occur naturally in the environment, or used specifically in a lab to transfer genetic material between bacteria. This allows one to observe antibiotic resistance as well as how they can adapt to their new surroundings. The transfer of genetic material between bacteria occurs in a small circular piece of DNA called the plasmid. Objective: In this experiment, new genes were transferred into the bacterium E. coli in order to observe new protein development. Specific genes are expressed using the pGLO plasmid. The following genes were identified as Ori, Bla, GFP, and AraC. Materials: Agar Plates pGLO plasmid E. Coli Arabinose Ampicillin…show more content…
To the +pGLO test tube, 10 microliters of the pGLO plasmid was added to create the transformation. Both test tubes were placed on ice in order to cool the solution for 30 minutes. After each of the test tubes cooled, they were heat shocked at 42 degrees in a water bath for 2 minutes. They were then placed back on ice for an additional two minutes and 500 microliters of LB was added to each tube. To allow phenotypic lag, the test tubes were placed in a water bath at 37 degrees celsius for 45 minutes. The preparation of each agar plate was set up using the following information: Plate 1: LB+Amp (tan) plate: +pGLO → add 100 microliters from (+) test tube Plate 2: LB+Amp+Arabinose (green) plate: +pGLO→ add 100 microliters from (+) test tube Plate 3: LB+Amp(tan) plate: -pGLO→ add 100 microliters from (-) test tube Plate 4: LB(pink) plate: -pGLO→ add 100 microliters from (-) test tube 100 microliters of the E. Coli culture was then spread over each plate

More about Pglo Lab

Open Document