eradication failures. This paper is a literature review of the ultra structure and morphology of the bacteria and how it develops resistance to antibiotics such as clarithromycin, metronidazole, amoxicillin and levofloxacin. It also reviews the action of these antibiotics and their prevalence rate of resistance to Helicobacter pylori. INTRODUCTION Helicobacter pylori known previously as Campylobacter pylori, is a Gram-negative bacteria mostly found in the stomach of humans. The bacterium is usually