The Levodopa effervescent floating tablets were prepared using different low density polymers (POLYOX different grades) in various drug polymer ratios for prolongation of gastric residence time and to improve the patience compliance.
The Levodopa effervescent floating tablets were prepared by direct compression method. The floating tablets were evaluated for friability, thickness, hardness, weight variation test, drug content,in vitro release and floating properties. The drug excipients compatability was evaluated by DSC and FT-IR study. Results
All the batches showed compliance with pharmacopoeia standards. Formulation F4 containing PEO WSR 303 in 1:1 drug polymer ratio showed controlled drug release for 12h (99.15%) emerging as best formulation. Among all the formulations, formulation F4 which contains PEO WSR 303 releases the drugs which follow…show more content… The average thickness and standard deviation were reported.
Tablet hardness was measured using a Monsanto hardness tester. The crushing strength of the 5 Levodopa floating tablets with known weight and thickness of each formulation were recorded in kg/cm2 and the average hardness and standard deviation were reported.
Friability Ten Levodopa floating Levodopa floating tablets were selected from each batch and weighed. Each batch of tablets was rotated at 25 rpm for 4 minutes (100 revolutions) in the Roche friabilator. The Levodopa tablets were then dusted and re-weighed to determine the loss in weight. Friability was then calculated as percent weight loss from the original tablets.
Percentage friability = (Initial weight – Final weight) × 100