Dopamine Synthesis

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Dopamine plays a key role in biochemical hypotheses of schizophrenia [7]. The dopamine is a catecholamine neurotransmitter found in neurons of both the central and peripheral nervous systems. It is stored in vesicles in axon terminals and released when the neuron is depolarized. Dopamine interacts with specific membrane receptors to produce its effects. These effects are terminated by re-uptake into the presynaptic neuron by a dopamine transporter or by metabolic inactivation by monoamine oxidase B (MAO-B) or catechol-0-methyltransferase [8]. Hyperactivity in the mesolimbic dopamine pathway is specifically proposed as the mediator of positive symptoms of schizophrenia. Recently, hypoactivity in the mesocortical dopamine pathway is hypothesized
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