ANTI-EPILEPTIC ACTIVITY OF BARRINGTONIA ASIATICA (L.)
G. Sandhya Rani*,Thirupathi Gorre
*Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, Warangal, A.P., India.
Objective: To investigate the hepatoprotective activity and acute oral toxicity of methanolic extract of aerial parts of The present report is an investigation of anti seizure activity of Barringtonia asiatica (L.), is a well known plant which is being used in Indian Traditional Medicines for epilepsy, nervous disorders, bronchitis and liver ailments. Method:The methanolic (90%) extract of Barringtonia asiatica (L.) (MEBA) was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in…show more content… In India, studies have reported the prevalence rate of epilepsy varying from 1710 to 9780 cases per million populations . Despite the optimal use of available antiepileptic drugs (AEDs), many patients with epilepsy fail to experience seizure control. Moreover, many patients suffer with the strong side effects of chronic treatment, which may include chronic toxicity, cognitive impairment, sedation and teratogenesis  .The increasing knowledge on the basic mechanisms of epilepsy, the most important convulsive disorder, has led to the rational development of compounds that block seizure onset or spread targeting specific neuronal substrates [4,5].
There is still a great demand for new anticonvulsant drugs, as the existing drugs fail to treat all types of convulsive disorders . Medicinal plants used for the therapy of epilepsy in traditional medicine have been shown to possess promising anticonvulsant activities in animal models and can be invaluable sources of new antiepileptic