Ferula Asafoetida Case Study

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REFERENCE ID: 2015-04758 TITLE:- EFFICACY OF A Ferula asafoetida linn FORMULATION IN MOUSE MODELS OF LEARNING AND MEMORY: “COGNITIDA” STUDY INTRODUCTION- Asafoetida which is also known as Ferula Asafoetida Linn is the dried latex extracted from the tap root of the Ferula plant .It is known to possess medicinal qualities Asafoetida resin is produced by solidifying juice that comes out of cuts made in the plant’s living roots which is then dried and powdered. The commercially available powder form is used for flavouring in Indian cuisine. Asafoetida is known to improve memory and learning from previous studies1 . This study is to elucidate the mechanism of action of asafoetida in improving memory and operant learning . OBJECTIVES- Primary…show more content…
for 2 weeks); vitamin C group (125 mg/kg i.p. for 2 weeks, in aqueous solution at pH 7); Asafoetida group ‘x’ mg/kg orally for ‘n’ days* .The pretreatment evaluation will serve as control values: for evaluation of memory & learning, the Y-maze and passive avoidance responses will be used. The Novelty Preference Test will be evaluated using Y maze and SMART video tracking software; Passive Avoidance Response (PAR) will be evaluated using Shutavoid software and a shuttle box. Acetylcholinesterase (AChE) Inhibition will be compared with known inhibitors of the enzyme (Donepezil) in order to elucidate the probable mechanism of action of asafetida in cholinergic system. This will be correlated with cognitive improvements on PAR & Y-Maze tests before and after drug treatments, and also with those of Donepezil, a central inhibitor of AChE from the pilot…show more content…
Vijayalakshmi, Adiga, S., Bhat, P., Chaturvedi, A., Bairy, K. L., & Kamath, S. (2012). Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian Journal of Pharmacology, 44(1), 82–7. doi:10.4103/0253-7613.91873 2. F. E. Harrison, A. H. Hosseini, M. P. McDonald, and J. M. May, Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice, Pharmacol Biochem Behav. 2009 October ; 93(4): 443–450. doi:10.1016/j.pbb.2009.06.006 3.Dong, H., Yuede, C. M., Coughlan, C. A., Murphy, K. M., & John, G. (2010). Effects of Donepezil on Amyloid-β and Synapse Density in the Tg2576 Mouse Model of Alzheimer's Disease, NIH Public Access, 169–178. doi:10.1016/j.brainres.2009.09.097.Effects 4.Jean Strelitz, Lawrence S. Engel, and Matthew C. Keifer. (2014). Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers, Occup Environ Med. 2014 December; 71(12): 842–847. doi:10.1136/oemed-2014-102315.NIH Public

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